GANT 58
GANT 58 (NSC 75503) is a potent GLI antagonist that inhibits GLI1-induced transcription with IC50 of 5 μM[1].
Product Specifications
CAS Number
64048-12-0
Product Name Alternative
NSC 75503
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Gli
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GANT-58.html
Purity
99.37
Solubility
DMSO : 9.09 mg/mL (ultrasonic) |Ethanol : 20 mg/mL (ultrasonic)
Smiles
C1(C2=C(C(C3=CC=NC=C3)=C(S2)C4=CC=NC=C4)C5=CC=NC=C5)=CC=NC=C1
Molecular Formula
C24H16N4S
Molecular Weight
392.48
Precautions
H315, H319, H335
References & Citations
[1]Lauth M, et al. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc Natl Acad Sci U S A. 2007 May 15;104 (20) :8455-60.|[2]Joo J, et al. GLI1 is a central mediator of EWS/FLI1 signaling in Ewing tumors. PLoS One. 2009 Oct 27;4 (10) :e7608.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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