FCCP
FCCP is an uncoupler of oxidative phosphorylation (OXPHOS) in mitochondria. FCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation[1].
Product Specifications
CAS Number
370-86-5
Product Name Alternative
Carbonyl cyanide 4- (trifluoromethoxy) phenylhydrazone
UNSPSC
12352005
Hazard Statement
H301, H317, H413
Target
Mitochondrial Metabolism; Oxidative Phosphorylation; PINK1/Parkin
Type
Reference compound
Related Pathways
Autophagy; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/FCCP.html
Concentration
10mM
Purity
99.70
Solubility
DMSO : ≥ 100 mg/mL|Ethanol : ≥ 33.3 mg/mL
Smiles
N#C/C(C#N)=N/NC1=CC=C(OC(F)(F)F)C=C1
Molecular Formula
C10H5F3N4O
Molecular Weight
254.17
Precautions
H301, H317, H413
References & Citations
[1]Connop BP et al.Novel effects of FCCP [carbonyl cyanide p- (trifluoromethoxy) phenylhydrazone] on amyloid precursor protein processing. J Neurochem. 1999 Apr;72 (4) :1457-65.|[2]Tanpradit N, et al. Carbonyl cyanide 4- (trifluoromethoxy) phenylhydrazone (FCCP) pre-exposure ensures follicle integrity during in vitro culture of ovarian tissue but not during cryopreservation in the domestic cat model. J Assist Reprod Genet. 2016 Dec;33 (12) :1621-1631. Epub 2016 Sep 17.|[3]Kondapalli C, et al. PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65. Open Biol. 2012 May;2 (5) :120080.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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