FCCP

FCCP is an uncoupler of oxidative phosphorylation (OXPHOS) in mitochondria. FCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation[1].

Product Specifications

CAS Number

[370-86-5]

Product Name Alternative

Carbonyl cyanide 4- (trifluoromethoxy) phenylhydrazone

UNSPSC

12352005

Hazard Statement

H301, H317, H413

Target

Mitochondrial Metabolism; Oxidative Phosphorylation; PINK1/Parkin

Type

Reference compound

Related Pathways

Autophagy; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/FCCP.html

Concentration

10mM

Purity

99.70

Solubility

DMSO : ≥ 100 mg/mL|Ethanol : ≥ 33.3 mg/mL

Smiles

N#C/C(C#N)=N/NC1=CC=C(OC(F)(F)F)C=C1

Molecular Formula

C10H5F3N4O

Molecular Weight

254.17

Precautions

H301, H317, H413

References & Citations

[1]Connop BP et al.Novel effects of FCCP [carbonyl cyanide p- (trifluoromethoxy) phenylhydrazone] on amyloid precursor protein processing. J Neurochem. 1999 Apr;72 (4) :1457-65.|[2]Tanpradit N, et al. Carbonyl cyanide 4- (trifluoromethoxy) phenylhydrazone (FCCP) pre-exposure ensures follicle integrity during in vitro culture of ovarian tissue but not during cryopreservation in the domestic cat model. J Assist Reprod Genet. 2016 Dec;33 (12) :1621-1631. Epub 2016 Sep 17.|[3]Kondapalli C, et al. PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65. Open Biol. 2012 May;2 (5) :120080.