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Anti-Secretogranin II Antibody

Rabbit Polyclonal Antibody specific to Secretogranin II

Product Specifications

Product Name Alternative

Chromogranin-C, Secretogranin II, SgII [Cleaved into: Secretoneurin

Gene Name

SCG2

NCBI Gene ID

<a href="https://www.ncbi.nlm.nih.gov/gene/?term=SCG2">SCG2</a>

UniProt

P13521

Cellular Locus

Secreted. Note=Neuroendocrine and endocrine secretory granules.

Host

Rabbit

Reactivity

Human, Rat, Squirrel Monkey

Immunogen

Synthetic peptide derived from the N-terminus of mature SgII protein: QRNQLLGKEPDLRLENVQK (Accession no. AAA36607).

Target Antigen

Secretogranin-2

Target

Secretogranin II

Clonality

Polyclonal

Type

Antibody

Applications

WB, IHC

Field of Research

Hormones/Proteins

Purification Method

Purified by peptide immuno-affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. {PubMed:19357184}.

Additionnal Information

Immunoblotting: use at 0.5-1.0ug/mL. <br><br>Immunohistochemistry: use at 2-5ug/mL.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C to -70°C. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.qedbio.com/wp-content/uploads/pdf/26107.pdf

Specificity

This antibody recognizes human, rat, and squirrel monkey SgII.

Formulation

PBS, pH 7 .4

Buffer pH

7.4

Target Background

Secretogranin II (SgII), encoded by the gene SCG2, is a member of the granin family of neuroendocrine secretory proteins. The granin family also includes chromogranin A (CgA), chromogranin B (CgB), and several other secretogranin-like proteins. Studies in rodents suggest that the full-length protein, SgII, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. SgII occurs in a variety of neoplasms arising from endocrine and neuroendocrine cells and can be a useful histological tumor marker for those cells.

CAS Number

9007-83-4

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