Diphyllin
Diphyllin is an orally active V-ATPase inhibitor (IC50=17 nM) and HIV-1 inhibitor (IC50=0.38 μM) . Diphyllin blocks the acidification of osteoclast lysosomes and bone resorption lacunas (IC50=0.6 nM for acid influx inhibition), thereby inhibiting bone resorption. Diphyllin can effectively inhibit osteoclast-mediated bone resorption and has no effect on osteoblastic bone formation. Diphyllin can be used in the research of bone metabolism-related diseases and has the potential to inhibit diseases related to excessive bone resorption[1][2][3][4].
Product Specifications
CAS Number
22055-22-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
HIV; Influenza Virus; Proton Pump; VSV
Type
Natural Products
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/diphyllin.html
Purity
99.90
Solubility
DMSO : 14.29 mg/mL (ultrasonic)
Smiles
O=C1OCC2=C(O)C3=CC(OC)=C(OC)C=C3C(C4=CC=C(OCO5)C5=C4)=C12
Molecular Formula
C21H16O7
Molecular Weight
380.35
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
HIV-1
Available Sizes
Frequently Asked Questions
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