Thrombin, Pig blood

Rabbit Thrombin is a Na+-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Thrombin recognition sequence and can be used to digest GST-tagged proteins[1].

Product Specifications

CAS Number

[9002-04-4]

UNSPSC

12352204

Target

Protease Activated Receptor (PAR) ; Thrombin

Type

Enzyme

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/thrombin-pig-blood.html

Purity

88.00

Solubility

H2O : ≥ 100 mg/mL

Smiles

[Thrombin,Pigblood]

References & Citations

[1]Coughlin SR. Thrombin signalling and protease-activated receptors. Nature. 2000 Sep 14;407 (6801) :258-64.|[2]Lundblad RL, et al. A review of the therapeutic uses of thrombin. Thromb Haemost. 2004 May;91 (5) :851-60.|[3]Golderman V, et al. Thrombin and the Protease-Activated Receptor-1 in Organophosphate-Induced Status Epilepticus. J Mol Neurosci. 2018 Dec 4.|[4]Chen K, et al., Exosite 2-Directed Ligands Attenuate Protein C Activation by the Thrombin-Thrombomodulin Complex. Biochemistry. 2017 Jun 20;56 (24) :3119-3128.|[5]Stahn S, et al., Teleocidin A2 inhibits human proteinase-activated receptor 2 signaling in tumor cells. Pharmacol Res Perspect. 2016 Jun 10;4 (4) :e00230.