Rabbit anti Human SLAP1 (Src-like Adaptor Protein-1)

Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. Interacts with EPHA2, VAV1, LCP2 and PDGFRB. The C-terminal domain is essential for the homodimerization and the interaction with CBL. While the interaction with CBL is apparently mediated via the hydrophobic region of this domain, the highly charged region is apparently required for the homodimerization. Expressed in lung and fetal brain. Weakly expressed in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas.

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.

1. Dragone, L.L., et al. 'Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent manner.' Proc. Natl. Acad. Sci. USA 2006, 103(48):18202-18207 2. Dragone, L.L., et al. 'SRC-like adaptor protein regulates B cell development and function.' J. Immunol. 2006, 176(1):335-345 3. Myers, M.D., et al. 'Src-like adaptor protein down-regulates T cell receptor (TCR)-CD3 expression by targets TCRzeta for degradation.' J. Cell. Biol. 2005, 170(2):285-294