B-Raf IN 19
B-Raf IN 19 (compound 31) is a BRAF inhibitor that inhibits BRAF (WT) and BRAF (V600E) (IC50: 0.57 μM and 0.28 μM, respectively) . B-Raf IN 19 inhibits MAPK signaling in melanoma cells[1].
Product Specifications
CAS Number
[708218-62-6]
UNSPSC
12352005
Target
P38 MAPK; Raf
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/stat3-in-19.html
Smiles
O=S(NC1=CC(SC2=CC=CC=C2)=C(C3=C1C=CC=C3)O)(C4=CC=CS4)=O
Molecular Formula
C20H15NO3S3
Molecular Weight
413.53
References & Citations
[1]Qin J, et al. Identification of a novel family of BRAF (V600E) inhibitors. J Med Chem. 2012 Jun 14;55 (11) :5220-30.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
B-Raf
Curated Selection
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