Acoramidis
Acoramidis (AG10) is an orally active and selective kinetic stabilizer of WT and V122I-TTR (transthyretin) . Acoramidis (AG10) is used in the study for transthyretin amyloidosis[1][2].
Product Specifications
CAS Number
1446711-81-4
Product Name Alternative
AG10
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Transthyretin (TTR)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/acoramidis.html
Purity
99.23
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC=C(F)C(OCCCC2=C(C)NN=C2C)=C1
Molecular Formula
C15H17FN2O3
Molecular Weight
292.31
Precautions
H315, H319, H335
References & Citations
[1]Sravan C Penchala, et al. AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. Proc Natl Acad Sci U S A. 2013 Jun 11;110 (24) :9992-7.|[2]Jonathan C Fox, et al. First-in-Human Study of AG10, a Novel, Oral, Specific, Selective, and Potent Transthyretin Stabilizer for the Treatment of Transthyretin Amyloidosis: A Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study in Healthy Adult Volunteers. Clin Pharmacol Drug Dev. 2020 Jan;9 (1) :115-129.|[3]Stephen P Soltoff, et al. Evidence that tyrphostins AG10 and AG18 are mitochondrial uncouplers that alter phosphorylation-dependent cell signaling. J Biol Chem. 2004 Mar 19;279 (12) :10910-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
K2632607 1.0 µg DNA
WDR45LP1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)
Sign In for Pricing
View Details 
GTR15333073 1 Vial
Lentiviral human ACVR1B shRNA (UAS) - Lentiviral human ACVR1B shRNA (UAS, GFP) plasmid
Sign In for Pricing
View Details 