IA9

IA9 (human TREM-2 182-190) is a potent, CNS-penetrant TREM-2 inhibitor. IA9 can diminish the release of proinflammatory cytokines and suppress joint inflammation and damage in a Collagen (HY-P5003) -induced arthritis (CIA) mouse model. IA9 can be used for neuroinflammation PET imaging. IA9 can be used for Rheumatoid arthritis (RA) and neuroinflammation research[1][2].

Product Specifications

Product Name Alternative

Human TREM-2 182-190

UNSPSC

12352209

Target

TREM receptor

Type

Peptides

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ia9.html

Purity

98.36

Solubility

DMSO : 22.22 mg/mL (ultrasonic;adjust pH to 4 with 1 M HCL)

Smiles

O=C([C@@H](N)[C@H](CC)C)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)C)=O)C)=O)CC(C)C)=O)[C@H](CC)C)=O)CCCCN)=O)[C@H](CC)C)=O)CC(C)C)=O)CC1=CC=CC=C1

Molecular Formula

C51H88N10O10

Molecular Weight

1001.31

References & Citations

[1]Sigalov AB. Inhibition of TREM-2 Markedly Suppresses Joint Inflammation and Damage in Experimental Arthritis. Int J Mol Sci. 2022;23 (16) :8857. Published 2022 Aug 9.|[2]Zonghua Luo, et al. Development of a Ga-68 Labeled Peptide Tracer Targeting TREM2 for Neuroinflammation PET Imaging. Journal of Nuclear Medicine. Jun 2025, 66 (supplement 1) 251786.