Pomalidomide-5'-PEG8-C2-COOH
Pomalidomide-5'-PEG8-C2-COOH is an E3 Ligase Ligand-Linker Conjugates, consisting of Pomalidomide (HY-10984) and a linker. Pomalidomide-5'-PEG8-C2-COOH can be used for synthesis of PROTACs[1].
Product Specifications
CAS Number
[2138440-78-3]
UNSPSC
12352203
Hazard Statement
H302-H315-H319-H335
Target
E3 Ligase Ligand-Linker Conjugates
Type
ADC Related
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pomalidomide-5-peg8-c2-cooh.html
Purity
98.21
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O
Molecular Formula
C32H47N3O14
Molecular Weight
697.73
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Posternak G, et al. Functional characterization of a PROTAC directed against BRAF mutant V600E. Nat Chem Biol. 2020 Nov;16 (11) :1170-1178.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Available Sizes
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