3,4-Dihydroxyphenylglycol

3,4-Dihydroxyphenylglycol is a phenolic compound and antioxidant. 3,4-Dihydroxyphenylglycol can be extracted from olive oil. 3,4-Dihydroxyphenylglycol downregulates the expression of proinflammatory enzymes (iNOS, COX-2) and prevents the degradation of IκBα. 3,4-Dihydroxyphenylglycol has antioxidant properties. 3,4-Dihydroxyphenylglycol has shown positive effects on frozen-thawed ram sperm. 3,4-Dihydroxyphenylglycol can be used in the study of inflammatory-related diseases (such as ulcerative colitis) and reproductive health (sperm cryopreservation) [1][2][3].

Product Specifications

CAS Number

[28822-73-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

COX; IKK; NO Synthase

Type

Natural Products

Related Pathways

Immunology/Inflammation; NF-κB

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/4-_1,2-Dihydroxyethyl_benzene-1,2-diol.html

Purity

98.07

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C1=CC(=C(C=C1C(CO)O)O)O

Molecular Formula

C8H10O4

Molecular Weight

170.16

Precautions

H302, H315, H319, H335

References & Citations

[1]Aparicio-Soto M, et al. Naturally occurring hydroxytyrosol derivatives: hydroxytyrosyl acetate and 3,4-dihydroxyphenylglycol modulate inflammatory response in murine peritoneal macrophages. Potential utility as new dietary supplements. J Agric Food Chem. 2015 Jan 28;63 (3) :836-46.|[2]Arando A, et al. Effect of different olive oil-derived antioxidants (hydroxytyrosol and 3,4-dihydroxyphenylglycol) on the quality of frozen-thawed ram sperm. Cryobiology. 2019 Feb;86:33-39.|[3]Sánchez-Fidalgo S, et al. Effects of dietary virgin olive oil polyphenols: hydroxytyrosyl acetate and 3, 4-dihydroxyphenylglycol on DSS-induced acute colitis in mice. J Nutr Biochem. 2015 May;26 (5) :513-20.