DuP 747 (hydrochloride)
DuP 747 hydrochloride is an analgesic with selective kappa-opioid receptor agonist activity. DuP 747 showed less spiradoline-appropriate selection when administered SC, but showed a partial generalized response to spiradoline when administered IP or PO. The 5-hydroxy-desmethoxy metabolite of DuP 747 induced selection of the saline-appropriate lever only. The effects of DuP 747 suggest that its metabolites may play a major role in the similar responses to spiradoline after IP and PO administration[1].
Product Specifications
CAS Number
115904-74-0
UNSPSC
12352005
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dup-747-hydrochloride.html
Smiles
ClC(C=C1CC(N([C@H]2C3=CC=CC(OC)=C3CC[C@@H]2N4CCCC4)C)=O)=C(C=C1)Cl.Cl
Molecular Formula
C24H29Cl3N2O2
Molecular Weight
483.86
References & Citations
[1]Assessing spiradoline-like discriminative effects of DuP 747: influence of route of administration
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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