Hesperidin methylchalcone

Hesperidin methylchalcone (Hesperidin methyl chalcone) is an orally active flavonoid that has analgesic, anti-inflammatory and antioxidant properties. Hesperidin methylchalcone exhibits vasoprotective activity. Hesperidin methylchalcone inhibits oxidative stress, cytokine production and NF-κB activation. Hesperidin methylchalcone can be used for the research of gout disease[1][2].

Product Specifications

CAS Number

[24292-52-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

NF-κB

Type

Natural Products

Related Pathways

NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/hesperidin-methylchalcone.html

Purity

98.0

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

COC1=C(C(/C=C/C2=CC(O)=C(OC)C=C2)=O)C(O)=CC(O[C@H](O3)[C@H](O)[C@@H](O)[C@H](O)[C@H]3CO[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)=C1

Molecular Formula

C29H36O15

Molecular Weight

624.59

Precautions

H302, H315, H319, H335

References & Citations

[1]Bussmann AJC, et al. The Flavonoid Hesperidin Methyl Chalcone Targets Cytokines and Oxidative Stress to Reduce Diclofenac-Induced Acute Renal Injury: Contribution of the Nrf2 Redox-Sensitive Pathway. Antioxidants (Basel) . 2022 Jun 27;11 (7) :1261.|[2]Ruiz-Miyazawa KW, et al. Hesperidin Methylchalcone Suppresses Experimental Gout Arthritis in Mice by Inhibiting NF-κB Activation. J Agric Food Chem. 2018 Jun 27;66 (25) :6269-6280.