Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Dauricine

Dauricine, a bisbenzylisoquinoline alkaloid in Menispermum dauricum, possesses anti-inflammatory activity. Dauricine inhibits cell proliferation and invasion, and induces apoptosis by suppressing NF-κB activation in a dose- and time-dependent manner in colon cancer[1].

Product Specifications

CAS Number

524-17-4

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; NF-κB; Oxidative Phosphorylation

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dauricine.html

Purity

99.75

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC=C(C[C@H]2N(C)CCC3=C2C=C(OC)C(OC)=C3)C=C1OC4=CC=C(C[C@H]5N(C)CCC6=C5C=C(OC)C(OC)=C6)C=C4

Molecular Formula

C38H44N2O6

Molecular Weight

624.77

Precautions

H302, H315, H319, H335

References & Citations

[1]Yang Z, et al. Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF-kappaB signaling pathway in colon cancer cells. J Cell Physiol. 2010 Oct;225 (1) :266-75.|[2]Chen C, et al. Dauricine Attenuates Spatial Memory Impairment and Alzheimer-Like Pathologies by Enhancing Mitochondrial Function in a Mouse Model of Alzheimer's Disease. Front Cell Dev Biol. 2021 Feb 5;8:624339. |[3]Li W, et al. Dauricine upregulates the chemosensitivity of hepatocellular carcinoma cells: Role of repressing glycolysis via miR-199a:HK2/PKM2 modulation. Food Chem Toxicol. 2018 Nov;121:156-165.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

MID1IP1 (NM_021242) Human Over-expression Lysate
LC429650 20 µg

MID1IP1 (NM_021242) Human Over-expression Lysate

Sign In for Pricing
View Details
Chromogranin A (CHGA/413), Biotin conjugate, 0.1mg/mL
BNCB0413-500 1x 500 µL

Chromogranin A (CHGA/413), Biotin conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Frozen Tissue Sections, Liver
CS519987 5x 5 µm

Frozen Tissue Sections, Liver

Sign In for Pricing
View Details
HSV1 (Herpes Simplex Virus Type I) (HSVI/2095), CF640R conjugate, 0.1mg/mL
BNC402095-500 1x 500 µL

HSV1 (Herpes Simplex Virus Type I) (HSVI/2095), CF640R conjugate, 0.1mg/mL

Sign In for Pricing
View Details
SIRT1 Human Gene Knockout Kit (CRISPR)
KN218134RB 1 Kit

SIRT1 Human Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
N-Cbz-O-Bzl-L-Glu-S-Bzl-L-Cys-Gly[13C2,15N]-OBzl
TRC-C215102-1MG 1 mg

N-Cbz-O-Bzl-L-Glu-S-Bzl-L-Cys-Gly[13C2,15N]-OBzl

Sign In for Pricing
View Details