TF-S14
TF-S14 is a reverse agonist of RORγt. TF-S14 reduces Th17 cell-associated cytokine production, including IL-17A, IL-21, and IL-22 by binding to and inhibiting RORγt activity. TF-S14 can be used in the study of autoimmune diseases and rejection in allotransplantation[1].
Product Specifications
CAS Number
2425563-60-4
UNSPSC
12352005
Target
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tf-s14.html
Smiles
O=C(N1CC[C@@H](C)C[C@H]1C)C2=C(NC(C3=CN=CC=C3)=O)SC4=C2CCCC4
Molecular Formula
C22H27N3O2S
Molecular Weight
397.53
References & Citations
[1]Fouda A, et al. RORγt inverse agonist TF-S14 inhibits Th17 cytokines and prolongs skin allograft survival in sensitized mice[J]. Communications Biology, 2024, 7 (1) : 454.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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