Quinine (hydrochloride)

Quinine (hydrochloride) is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine (hydrochloride) is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM[1][2].

Product Specifications

CAS Number

[130-89-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Dengue Virus; Flavivirus; Parasite; Potassium Channel

Type

Reference compound

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/quinine-hydrochloride.html

Purity

98.0

Smiles

O[C@H](C1=CC=NC2=C1C=C(OC)C=C2)[C@@]3([H])[N@](C[C@@H]4C=C)CC[C@H]4C3.Cl

Molecular Formula

C20H25ClN2O2

Molecular Weight

360.88

Precautions

H302, H315, H319, H335

References & Citations

[1]Jhanwar, Deepika, et al. Chemoprevention of DMBA induced skin carcinogenesis in swiss albino mice by quinine sulfate. (2016) : 2636-2640.|[2]Shilu Malakar, et al. Drug repurposing of quinine as antiviral against dengue virus infection. Virus Res. 2018 Aug 15;255:171-178. doi: 10.1016/j.virusres.2018.07.018. Epub 2018 Jul 25.