Anti-B-Cell Maturation protein (BCMA) Antibody

Rabbit Polyclonal Antibody specific to BCMA

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

B-cell maturation protein, CD antigen CD269

Gene Name

TNFRSF17

NCBI Gene ID

<a href="https://www.ncbi.nlm.nih.gov/gene/?term=TNFRSF17">TNFRSF17</a>

UniProt

Q02223

Cellular Locus

Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Note=Perinuclear Golgi-like structures.

Host

Rabbit

Reactivity

Human

Immunogen

A synthetic peptide corresponding to the carboxy terminus of human BCMA.

Target Antigen

Tumor necrosis factor receptor superfamily member 17

Target

B-Cell Maturation protein (BCMA)

Clonality

Polyclonal

Isotype

IgG

Type

Antibody

Applications

ELISA, WB, IHC-P, IF

Field of Research

Growth Factors, Cytokines, Receptors

Purification Method

Purified by peptide immuno-affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. {PubMed:10801128, PubMed:10903733, PubMed:10973284}.

Additionnal Information

Western Blot: Use at 2-5 ug/ml. A band of approximately 27 kD is detected using K562 cell lysate as a Positive control.

Storage Conditions

Store at 4°C; stable for one year

Specificity

This antibody recognizes human BCMA (B Cell Maturation Protein). BCMA is a receptor for BAFF and April, two novel members of the TNF superfamily of proteins regulating immune response and the induction of apoptosis through the activation of NF-kappaB and c-jun N- terminal kinase.