INT-777
INT-777 is a potent TGR5 agonist with an EC50 of 0.82 μM[1].
Product Specifications
CAS Number
1199796-29-6
Product Name Alternative
S-EMCA
UNSPSC
12352211
Target
G protein-coupled Bile Acid Receptor 1
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/INT-777.html
Concentration
10mM
Purity
99.80
Solubility
DMSO : 100 mg/mL (ultrasonic) |Ethanol : ≥ 50 mg/mL
Smiles
O[C@@H]1CC[C@@]2(C)[C@@]([C@@H](CC)[C@@H](O)[C@]3([H])[C@]2([H])C[C@H](O)[C@@]4(C)[C@@]3([H])CC[C@@H]4[C@H](C)C[C@H](C)C(O)=O)([H])C1
Molecular Formula
C27H46O5
Molecular Weight
450.65
References & Citations
[1]Pellicciari R, et al. Discovery of 6alpha-ethyl-23 (S) -methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity. J Med Chem. 2009 Dec 24;52 (24) :7958-61.|[2]Thomas C, et al. TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab. 2009 Sep;10 (3) :167-77.|[3]Duboc H, et al.Reduction of epithelial secretion in male rat distal colonic mucosa by bile acid receptor TGR5 agonist, INT-777: role of submucosal neurons. Neurogastroenterol Motil. 2016 Jun 3. doi: 10.1111/nmo.|[4]Baiqiang Li, et al. INT-777, a bile acid receptor agonist, extenuates pancreatic acinar cells necrosis in a mouse model of acute pancreatitis. Biochem Biophys Res Commun. 2018 Sep 3;503 (1) :38-44.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
SC327796 10 µg
AKR7L (untagged)-Human aldo-keto reductase family 7-like (AKR7L) transcript variant 1
Sign In for Pricing
View Details 