L-692585
L-692585 is a potent and nonpeptidyl growth hormone secretagogue receptor (GHS-R1a) agonist, with a Ki of 0.8 nM. L-692585 acts directly on somatotropes causing GH release[1][2].
Product Specifications
CAS Number
145455-35-2
UNSPSC
12352005
Target
GHSR
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/l-692585.html
Purity
99.32
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)(NC[C@H](O)C)CC(N[C@H]1C(N(CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2)C5=CC=CC=C5CC1)=O)=O
Molecular Formula
C32H37N7O3
Molecular Weight
567.68
References & Citations
[1]Smith RG, et, al. Peptidomimetic regulation of growth hormone secretion. Endocr Rev. 1997 Oct; 18 (5) : 621-45.|[2]Glavaski-Joksimovic A, et, al. Mechanism of action of the growth hormone secretagogue, L-692,585, on isolated porcine somatotropes. J Endocrinol. 2002 Dec; 175 (3) : 625-36.|[3]Jacks T, et, al. Effects of acute and repeated intravenous administration of L-692,585, a novel non-peptidyl growth hormone secretagogue, on plasma growth hormone, IGF-1, ACTH, cortisol, prolactin, insulin, and thyroxine levels in beagles. J Endocrinol. 1994 Nov; 143 (2) : 399-406.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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