L-692585

L-692585 is a potent and nonpeptidyl growth hormone secretagogue receptor (GHS-R1a) agonist, with a Ki of 0.8 nM. L-692585 acts directly on somatotropes causing GH release[1][2].

Product Specifications

CAS Number

[145455-35-2]

UNSPSC

12352005

Target

GHSR

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/l-692585.html

Purity

99.32

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C)(NC[C@H](O)C)CC(N[C@H]1C(N(CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2)C5=CC=CC=C5CC1)=O)=O

Molecular Formula

C32H37N7O3

Molecular Weight

567.68

References & Citations

[1]Smith RG, et, al. Peptidomimetic regulation of growth hormone secretion. Endocr Rev. 1997 Oct; 18 (5) : 621-45.|[2]Glavaski-Joksimovic A, et, al. Mechanism of action of the growth hormone secretagogue, L-692,585, on isolated porcine somatotropes. J Endocrinol. 2002 Dec; 175 (3) : 625-36.|[3]Jacks T, et, al. Effects of acute and repeated intravenous administration of L-692,585, a novel non-peptidyl growth hormone secretagogue, on plasma growth hormone, IGF-1, ACTH, cortisol, prolactin, insulin, and thyroxine levels in beagles. J Endocrinol. 1994 Nov; 143 (2) : 399-406.