Purpurogallin

Purpurogallin is a naturally phenol extracted from the plants of Quercus spp, has potent xanthine oxidase (XO) inhibitory activity with an IC50 of 0.2 μM. Purpurogallin has antioxidant and anti-inflammatory effects[1][2][3].

Product Specifications

CAS Number

[569-77-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Xanthine Oxidase

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/purpurogallin.html

Purity

98.06

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C(O)=CC=CC2=CC(O)=C(O)C(O)=C21

Molecular Formula

C11H8O5

Molecular Weight

220.18

Precautions

H302, H315, H319, H335

References & Citations

[1]Park HY, et al. Purpurogallin exerts anti‑inflammatory effects in lipopolysaccharide‑stimulated BV2 microglial cells through the inactivation of the NF‑κB and MAPK signaling pathways. Int J Mol Med. 2013 Nov;32 (5) :1171-8.|[2]Chang CZ, et al. Purpurogallin, a natural phenol, attenuates high-mobility group box 1 in subarachnoid hemorrhage induced vasospasm in a rat model. Int J Vasc Med. 2014;2014:254270.|[3]Honda S, et al. Conversion to purpurogallin, a key step in the mechanism of the potent xanthine oxidase inhibitory activity of pyrogallol. Free Radic Biol Med. 2017 May;106:228-235.