Cathepsin D

Cathepsin D (CTSD) is a lysosomal aspartic protease encoded by the CTSD gene. Cathepsin D regulates lysosomal protease activity. Loss of Cathepsin D leads to lysosomal dysfunction and the accumulation of various cellular proteins associated with neurodegenerative diseases. Cathepsin D is involved in breast cancer metastasis. Cathepsin D can be used in research on diseases such as breast cancer and stroke[1][2].

Product Specifications

CAS Number

[9025-26-7]

Product Name Alternative

CTSD

UNSPSC

12352204

Target

Biochemical Assay Reagents

Type

Enzyme

Related Pathways

Others

Field of Research

Cancer; Cardiovascular Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cathepsin-d.html

Solubility

10 mM in DMSO

Smiles

[CathepsinD]

References & Citations

[1]Hossain MI, et al. Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective. Autophagy. 2021 Jun;17 (6) :1330-1348.|[2]Rochefort H, et al. Cathepsin D: a protease involved in breast cancer metastasis. Cancer Metastasis Rev. 1990 Dec;9 (4) :321-31.