(Rac)-Taltobulin intermediate-1
Product Specifications
UNSPSC Description
(Rac)-Taltobulin intermediate-1 is an intermediate in the synthesis of Taltobulin (HY-15584). Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis[1].
Target Antigen
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rac-taltobulin-intermediate-1.html
Purity
99.11
Solubility
DMSO : ≥ 100 mg/mL
Smiles
OC(C(N(C(OC(C)(C)C)=O)C)C(C)(C)C1=CC=CC=C1)=O
Molecular Weight
307.39
References & Citations
[1]Loganzo F, et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003 Apr 15;63(8):1838-45.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-41045/Rac-Taltobulin-intermediate-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-41045/Rac-Taltobulin-intermediate-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
676487-35-7
Available Sizes
Curated Selection
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