GNE-8324
GNE-8324 is a selective GluN2A positive allosteric modulator. GNE-8324 selectively enhances NMDA receptor (NMDAR) -mediated synaptic responses in inhibitory but not excitatory neurons[1].
Product Specifications
CAS Number
[1698901-76-6]
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gne-8324.html
Purity
98.88
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C=C(CN(C2=CC=C(F)C=C2)CC)N=C3N1C(CCC4)=C4S3
Molecular Formula
C18H18FN3OS
Molecular Weight
343.42
References & Citations
[1]Lulu Yao, et al. Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity. Nat Commun. 2018 Oct 1;9 (1) :4000.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NMDA Receptor
Available Sizes
Curated Selection
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