COB-187

COB-187 is a potent, ATP-competitive and selective inhibitor of GSK-3β. COB-187 inhibits GSK-3 through a reversible and Cysteine (Cys) -199-dependent mechanism. COB-187 inhibits LPS induced cytokine production and SARS-CoV-2 spike protein-induced CXCL10 production[1].

Product Specifications

CAS Number

[1862177-86-3]

UNSPSC

12352005

Target

GSK-3

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Infection; Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cob-187.html

Purity

95.0

Smiles

OC1(CSC(N1CC2=CC=NC=C2)=S)C3=CC=CC=C3

Molecular Formula

C15H14N2OS2

Molecular Weight

302.41

References & Citations

[1]Mehrani R, et al. Capturing the Effects of Single Atom Substitutions on the Inhibition Efficiency of Glycogen Synthase Kinase-3β Inhibitors via Markov State Modeling and Experiments. J Chem Theory Comput. 2024 Jul 8.