Osthole (Standard)

Osthole (Standard) is the analytical standard of Osthole. This product is intended for research and analytical applications. Osthole (Osthol) is a natural antihistamine alternative. Osthole may be a potential inhibitor of histamine H1 receptor activity. Osthole also suppresses the secretion of HBV in cells.

Product Specifications

CAS Number

[484-12-8]

Product Name Alternative

Osthol (Standard) ; NSC 31868 (Standard)

UNSPSC

12352005

Target

Apoptosis; HBV; Histamine Receptor; Parasite; Reference Standards

Type

Reference Standards

Related Pathways

Anti-infection; Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others

Field of Research

Cancer; Infection; Endocrinology; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/osthole-standard.html

Smiles

O=C1C=CC2=CC=C(OC)C(C/C=C(C)\C)=C2O1

Molecular Formula

C15H16O3

Molecular Weight

244.29

References & Citations

[1]Kordulewska NK, et al. Changes in gene expression induced by histamine, fexofenadine and osthole: Expression of histamine H1 receptor, COX-2, NF-κB, CCR1, chemokine CCL5/RANTES and interleukin-1β in PBMC allergic and non-allergic patients. Immunobiology.|[2]Tang DZ, et al. Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling. J Bone Miner Res. 2010 Jun;25 (6) :1234-45.|[3]Sun W, et al. Osthole pretreatment alleviates TNBS-induced colitis in mice via both cAMP/PKA-dependent and independent pathways. Acta Pharmacol Sin. 2017 Aug;38 (8) :1120-1128.|[4]Zhang ZR, et al. Osthole: A Review on Its Bioactivities, Pharmacological Properties, and Potential as Alternative Medicine. Evid Based Complement Alternat Med. 2015;2015:919616.