BAY-8002

BAY-8002 is a potent, selective, orally active inhibitor of monocarboxylate transporter 1 (MCT1), with an IC50 of 85 nM in the MCT1-expressing DLD-1 cells, displays excellent selectivity against MCT4. Anti-tumor activity[1].

Product Specifications

CAS Number

[724440-27-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Monocarboxylate Transporter

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/BAY-8002.html

Purity

98.84

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(O)C1=CC=CC=C1NC(C2=CC(S(=O)(C3=CC=CC=C3)=O)=CC=C2Cl)=O

Molecular Formula

C20H14ClNO5S

Molecular Weight

415.85

Precautions

H302, H315, H319, H335

References & Citations

[1]Quanz M, et al. Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of Resistance. Mol Cancer Ther. 2018 Nov;17 (11) :2285-2296.