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G15

G15 is a high affinity and selective G-protein-coupled estrogen receptor (GPER/GPR30) antagonist with a Ki of 20 nM[1][2].

Product Specifications

CAS Number

[1161002-05-6]

UNSPSC

12352005

Hazard Statement

H302, H319, H332, H372, H400

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/g15.html

Purity

99.0

Solubility

DMSO : 41.67 mg/mL (ultrasonic)

Smiles

BrC1=C([C@@H]2NC3=C(C=CC=C3)[C@@]4([H])[C@]2([H])CC=C4)C=C5OCOC5=C1

Molecular Formula

C19H16BrNO2

Molecular Weight

370.24

Precautions

H302, H319, H332, H372, H400

References & Citations

[1]Liu C, et al. G-Protein-Coupled Estrogen Receptor Antagonist G15 Decreases Estrogen-Induced Development of Non-Small Cell Lung Cancer. Oncol Res. 2019 Feb 21;27 (3) :283-292|[2]Girgert R, et al. Estrogen Signaling in ERα-Negative Breast Cancer: ERβ and GPER. Front Endocrinol (Lausanne) . 2019 Jan 9;9:781.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-103449/G15-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-103449/G15-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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