OUL232
OUL232 is a potent inhibitor of mono-ARTs PARP7, PARP10, PARP11, PARP12, PARP14, and PARP15. OUL232 is the most potent PARP10 inhibitor described to date (IC50=7.8 nM), as well as the first PARP12 inhibitor ever reported[1].
Product Specifications
CAS Number
943119-42-4
UNSPSC
12352005
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/oul232.html
Purity
99.86
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
NC1=NN=C2N1C3=C(C(OC)=CC=C3OC)S2
Molecular Formula
C10H10N4O2S
Molecular Weight
250.28
References & Citations
[1]Murthy S, et al. [1,2,4]Triazolo[3,4-b]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes. J Med Chem. 2023 Jan 4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1; PARP10; PARP14; PARP15; PARP2; PARP3; PARP4; PARP7; TNKS1/PARP5A; TNKS2/PARP5B
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