(±) -Naringenin
(±) -Naringenin is an orally available anti-inflammatory agent that can regulate both acute and chronic inflammation responses, while also showing antioxidant, neuroprotective, liver-protective, and anti-cancer effects. (±) -Naringenin promotes vasodilation in endothelial cells by activating BKCa channels in muscle cells. It also exerts protective effects against experimental colitis by inhibiting Toll-like receptor 4/NF-κB signaling, making it useful in studies related to sepsis, fulminant hepatitis, fibrosis, and cancer research[1][2][3].
Product Specifications
CAS Number
67604-48-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Caspase; NF-κB; Potassium Channel; Toll-like Receptor (TLR)
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; NF-κB
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/racemic-naringenin.html
Purity
99.83
Solubility
DMSO : 120 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
O=C1CC(C2=CC=C(O)C=C2)OC3=CC(O)=CC(O)=C13
Molecular Formula
C15H12O5
Molecular Weight
272.26
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Phase 1
Isoform
Caspase 9; NF-κB
Available Sizes
Frequently Asked Questions
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