(±) -Naringenin

(±) -Naringenin is an orally available anti-inflammatory agent that can regulate both acute and chronic inflammation responses, while also showing antioxidant, neuroprotective, liver-protective, and anti-cancer effects. (±) -Naringenin promotes vasodilation in endothelial cells by activating BKCa channels in muscle cells. It also exerts protective effects against experimental colitis by inhibiting Toll-like receptor 4/NF-κB signaling, making it useful in studies related to sepsis, fulminant hepatitis, fibrosis, and cancer research[1][2][3].

Product Specifications

CAS Number

[67604-48-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Caspase; NF-κB; Potassium Channel; Toll-like Receptor (TLR)

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; NF-κB

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/racemic-naringenin.html

Purity

99.83

Solubility

DMSO : 120 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

O=C1CC(C2=CC=C(O)C=C2)OC3=CC(O)=CC(O)=C13

Molecular Formula

C15H12O5

Molecular Weight

272.26

Precautions

H302, H315, H319, H335

References & Citations

[1]Saponara S, et al. (+/-) -Naringenin as large conductance Ca (2+) -activated K+ (BKCa) channel opener in vascular smooth muscle cells. Br J Pharmacol. 2006 Dec;149 (8) :1013-21.|[2]Wei Dou, et al. Protective effect of naringenin against experimental colitis via suppression of Toll-like receptor 4/NF-κB signalling. Br J Nutr. 2013 Aug;110 (4) :599-608.|[3]Mahzad Motallebi, et al. Naringenin: A potential flavonoid phytochemical for cancer therapy. Life Sci. 2022 Sep 15:305:120752.