Scyllatoxin

Scyllatoxin (Leiurotoxin I) is a peptide toxin, it can be isolated from the venom of the scorpion (Leiurus quinquestriatus hebraeus) . Scyllatoxin is a blocker of small-conductance KCa (SK) channel. Scyllatoxin enhances both norepinephrine (NE) and epinephrine (Epi) release in vivo[1].

Product Specifications

CAS Number

[142948-19-4]

Product Name Alternative

Leiurotoxin I

UNSPSC

12352209

Hazard Statement

H301-H311-H330

Target

Potassium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/scyllatoxin.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@H](N)C)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(NCC(N[C@H]1CCCCN)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)CC(C)C)=O)CO)=O)CCCNC(N)=N)=O)CSSC[C@H](NC2=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CC3=CNC=N3)=O)CCCCN)=O)C(C)C)=O)=O)CO)=O)CC(C)C)=O)CCC(N)=O)=O)CSSC[C@H](NC4=O)C(N[C@H]2CCC(O)=O)=O)=O)CCSC)=O)CCCNC(N)=N)=O)CC(C)C)=O)CC(N)=O)=O)CSC[C@H](NC1=O)C(N[C@H](C(NCC(N[C@H](C(N[C@H]4CCCCN)=O)CC(O)=O)=O)=O)[C@H](CC)C)=O)=O)CC5=CC=CC=C5

Molecular Formula

C142H237N45O39S7

Molecular Weight

3423.15

Precautions

P260-P264-P270-P271-P280-P284-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501

References & Citations

[1]Auguste P, et al. Scyllatoxin, a blocker of Ca (2+) -activated K+ channels: structure-function relationships and brain localization of the binding sites. Biochemistry. 1992 Jan 28;31 (3) :648-54.|[2]Akiyama T, et al. Role of Ca2+-activated K+ channels in catecholamine release from in vivo rat adrenal medulla. Neurochem Int. 2010 Jan;56 (2) :263-9.