Pitofenone

Pitofenone, a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from electric eel with Kis of 36 and 45 μM, respectively[1][2].

Product Specifications

CAS Number

[54063-52-4]

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pitofenone.html

Smiles

O=C(C1=CC=C(OCCN2CCCCC2)C=C1)C3=C(C=CC=C3)C(OC)=O

Molecular Formula

C22H25NO4

Molecular Weight

367.44

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

References & Citations

[1]Bal-Tembe S, et al. HL 752: a potent and long-acting antispasmodic agent. Bioorg Med Chem. 1997 Jul;5 (7) :1381-7.|[2]Punekar NS, et al. Acetylcholinesterase inhibition by pitofenone: a spasmolytic compound. Biotechnol Appl Biochem. 1991 Dec;14 (3) :378-82.