4-Acetylphenylboronic acid

4-Acetylphenylboronic acid is a potent inhibitor of carbonic anhydrases II (CA II), with IC50s of 246 μM and 281.40 μM for bovine CA II (bCA II) and human CA II (hCA II) . 4-Acetylphenylboronic acid can be obtained via mechanochemistry and solvent evaporation. 4-Acetylphenylboronic acid has a loss of the carbonyl group at 500-550 K[1][2][3].

Product Specifications

CAS Number

[149104-90-5]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Carbonic Anhydrase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/4-acetylphenylboronic-acid.html

Purity

99.98

Smiles

O=C(C1=CC=C(B(O)O)C=C1)C

Molecular Formula

C8H9BO3

Molecular Weight

163.97

Precautions

H315, H319, H335

References & Citations

[1]Saima Rasheed, et al. Identification, crystallization, and first X-ray structure analyses of phenyl boronic acid-based inhibitors of human carbonic anhydrase-II. Int J Biol Macromol. 2024 May;267 (Pt 1) :131268.|[2]Ofelia Hernández-Negrete, et al., New hydrate cocrystal of l-proline with 4-acetylphenylboronic acid obtained via mechanochemistry and solvent evaporation: An experimental and theoretical study, Journal of Solid State Chemistry, Volume 313, 2022.|[3]Alexander Wolfram, et al., Adsorption of Phenylboronic Acid Derivatives on Rutile TiO2 (110) J. Phys. Chem. C 2024, 128, 30, 12450–12470.