JA2
JA2 is an inhibitor of metalloendopeptidase 24.15 that can potentiate the hypotensive response to bradykinin in rat[1].
Product Specifications
CAS Number
277333-45-6
UNSPSC
12352005
Target
Neprilysin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ja2.html
Purity
99.94
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
OC(C=C1)=CC=C1C[C@H](NC(C(C)(C)NC([C@H](C)NC(C(O)=O)CCC2=CC=CC=C2)=O)=O)C(NC3=CC=C(C=C3)C(O)=O)=O
Molecular Formula
C33H38N4O8
Molecular Weight
618.68
References & Citations
[1]Alessandra Linardi, et al. Peptidase activities in rats treated chronically with N (omega) -nitro-L-arginine methyl ester (L-NAME) . Biochem Pharmacol. 2004 Jul 15;68 (2) :205-14.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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