CFM-1

CFM-1 is a small molecule antagonist of CARP-1/APC-2 binding with an EC50 value of 4.1 μM. CFM-1 induces G2M cell cycle arrest and suppresses viabilities of human breast cancer cells[1].

Product Specifications

CAS Number

1380448-60-1

UNSPSC

12352005

Target

APC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cfm-1.html

Smiles

O=C1NC2=C(C=C(Br)C=C2C)/C1=C(SC(N3)=S)\C3=O

Molecular Formula

C12H7BrN2O2S2

Molecular Weight

355.23

References & Citations

[1]Puliyappadamba VT, et al. Antagonists of anaphase-promoting complex (APC) -2-cell cycle and apoptosis regulatory protein (CARP) -1 interaction are novel regulators of cell growth and apoptosis. J Biol Chem. 2011 Nov 4;286 (44) :38000-38017.