Mecbotamab

Mecbotamab is a humanized IgG1-κ antibody targeting to AXL receptor tyrosine kinase (AXL) . Mecbotamab can serves as a conditionally active biologic (CAB), which can be conjugated with MMAE (HY-15162) via a cleavable linker, to form ADC Mecbotamab vedotin (BA3011) [1][2].

Product Specifications

CAS Number

[2460400-28-4]

Product Name Alternative

BA301

UNSPSC

12352203

Target

ADC Antibody; TAM Receptor

Type

Inhibitory Antibodies

Related Pathways

Antibody-drug Conjugate/ADC Related; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mecbotamab.html

Purity

99.9

Solubility

10 mM in DMSO|H2O

Smiles

[Mecbotamab]

Molecular Weight

(145.126 kDa)

References & Citations

[1]Shen G G, et al. Population pharmacokinetic and exposure-response safety analyses of mecbotamab vedotin (BA3011) in patients with advanced solid tumors[J]. 2023.|[2]Mecbotamab. IMGT/mAb-DB.