(S) - (+) -Dimethindene (maleate)

(S) - (+) -Dimethindene maleate, an enantiomer, is a potent M2-selective muscarinic receptor antagonist (pA2 = 7.86/7.74; pKi = 7.78) . (S) - (+) -Dimethindene maleate shows lower affinities for the muscarinic M1 (pA2 = 6.83/6.36; pKi = 7.08), the M3 (pA2 = 6.92/6.96; pKi = 6.70) and the M4 receptors (pKi = 7.00), respectively. (S) - (+) -Dimethindene maleate also is a histamine H1 receptor antagonist (pA2 = 7.48) [1].

Product Specifications

CAS Number

[136152-65-3]

UNSPSC

12352005

Target

Histamine Receptor; mAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/s-plus-dimethindene-maleate.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@H](C1=C(CCN(C)C)CC2=C1C=CC=C2)C3=NC=CC=C3.OC(/C=C\C(O)=O)=O

Molecular Formula

C24H28N2O4

Molecular Weight

408.49

References & Citations

[1]Pfaff O, et al. The (S) - (+) -enantiomer of dimethindene: a novel M2-selective muscarinic receptor antagonist. Eur J Pharmacol. 1995;286 (3) :229-240.|[2]Yang Y, et al. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency. Cell. 2017;169 (2) :243-257.e25.