CM398

CM398 is a highly selective, orally active sigma-2 receptor ligand (Ki=0.43 nM), with high sigma-1/sigma-2 selectivity rato (1000-fold) . CM398 shows notable affinity for dopamine (Ki=32.90 nM) and serotonin transporters (Ki=244.2 nM) . CM398 shows promising anti-inflammatory analgesic effects in the formalin model of inflammatory pain in mice[1].

Product Specifications

CAS Number

[1121931-70-1]

UNSPSC

12352005

Target

Sigma Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cm398.html

Purity

99.85

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1N(C)C2=C(N1CCCCN3CC4=CC(OC)=C(C=C4CC3)OC)C=CC=C2

Molecular Formula

C23H29N3O3

Molecular Weight

395.49

References & Citations

[1]Intagliata S, et al. Discovery of a Highly Selective Sigma-2 Receptor Ligand, 1- (4- (6,7-Dimethoxy-3,4-dihydroisoquinolin-2 (1H) -yl) butyl) -3-methyl-1H-benzo[d]imidazol-2 (3H) -one (CM398), with Drug-Like Properties and Antinociceptive Effects In Vivo. AAPS J. 2020;22 (5) :94. Published 2020 Jul 20.