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IYPTNGYTR (acetate)

IYPTNGYTR acetate, a deamidation-sensitive signature peptide, is a deamidation product of Trastuzumab. IYPTNGYTR acetate can be used to monitor in vivo Trastuzumab metabolism[1].

Product Specifications

UNSPSC

12352209

Target

Drug Metabolite

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/iyptngytr-acetate.html

Purity

99.41

Solubility

H2O : 125 mg/mL (ultrasonic)

Smiles

CC(O)=O.O=C(N(CCC1)[C@@H]1C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(N)=O)C(NCC(N[C@H](C(N[C@@H]([C@H](O)C)C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)CC(C=C2)=CC=C2O)=O)=O)=O)=O)[C@@H](NC([C@@H](N)[C@@H](C)CC)=O)CC(C=C3)=CC=C3O

Molecular Formula

C51H77N13O17

Molecular Weight

1144.23

References & Citations

[1]Bults P, et, al. LC-MS/MS-Based Monitoring of In Vivo Protein Biotransformation: Quantitative Determination of Trastuzumab and Its Deamidation Products in Human Plasma. Anal Chem. 2016 Feb 2;88 (3) :1871-7.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

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