AC-099 (hydrochloride)

AC-099 hydrochloride (compound 3) is a selective NPFF2R full agonist (EC50=1189 nM) and NPFF1R partial agonist (EC50=2370 nM) . AC-099 hydrochloride attenuates spinal nerve ligation-induced hypersensitivity in rats[1][2].

Product Specifications

CAS Number

[849335-07-5]

UNSPSC

12352005

Target

Neuropeptide FF Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ac-099-hydrochloride.html

Purity

99.92

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC(C1=CC(/C=N/NC(N)=N)=CC=C1Cl)(F)F.[H]Cl

Molecular Formula

C9H9Cl2F3N4

Molecular Weight

301.10

References & Citations

[1]Findeisen M, et al. Selective mode of action of guanidine-containing non-peptides at human NPFF receptors. J Med Chem. 2012 Jul 12;55 (13) :6124-36. |[2]Gaubert G, et al. Discovery of selective nonpeptidergic neuropeptide FF2 receptor agonists. J Med Chem. 2009 Nov 12;52 (21) :6511-4.