AC-099 (hydrochloride)
Product Specifications
UNSPSC Description
AC-099 hydrochloride (compound 3) is a selective NPFF2R full agonist (EC50=1189 nM) and NPFF1R partial agonist (EC50=2370 nM). AC-099 hydrochloride attenuates spinal nerve ligation-induced hypersensitivity in rats[1][2].
Target Antigen
Neuropeptide FF Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ac-099-hydrochloride.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(C1=CC(/C=N/NC(N)=N)=CC=C1Cl)(F)F.[H]Cl
Molecular Weight
301.10
References & Citations
[1]Findeisen M, et al. Selective mode of action of guanidine-containing non-peptides at human NPFF receptors. J Med Chem. 2012 Jul 12;55(13):6124-36. |[2]Gaubert G, et al. Discovery of selective nonpeptidergic neuropeptide FF2 receptor agonists. J Med Chem. 2009 Nov 12;52(21):6511-4.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-154829A/AC-099-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-154829A/AC-099-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
849335-07-5
Available Sizes
Curated Selection
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