AC-099 (hydrochloride)
AC-099 hydrochloride (compound 3) is a selective NPFF2R full agonist (EC50=1189 nM) and NPFF1R partial agonist (EC50=2370 nM) . AC-099 hydrochloride attenuates spinal nerve ligation-induced hypersensitivity in rats[1][2].
Product Specifications
CAS Number
[849335-07-5]
UNSPSC
12352005
Target
Neuropeptide FF Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ac-099-hydrochloride.html
Purity
99.92
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(C1=CC(/C=N/NC(N)=N)=CC=C1Cl)(F)F.[H]Cl
Molecular Formula
C9H9Cl2F3N4
Molecular Weight
301.10
References & Citations
[1]Findeisen M, et al. Selective mode of action of guanidine-containing non-peptides at human NPFF receptors. J Med Chem. 2012 Jul 12;55 (13) :6124-36. |[2]Gaubert G, et al. Discovery of selective nonpeptidergic neuropeptide FF2 receptor agonists. J Med Chem. 2009 Nov 12;52 (21) :6511-4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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