SHU 9119
SHU 9119 is a potent human melanocortin 3 and 4 receptors (MC3/4R) antagonist and a partial MC5R agonist; with IC50 values of 0.23, 0.06, and 0.09 nM for human MC3R, MC4R and MC5R, respectively.
Product Specifications
CAS Number
168482-23-3
UNSPSC
12352209
Target
Melanocortin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/SHU_9119.html
Purity
99.95
Solubility
H2O : 10 mg/mL (ultrasonic)
Smiles
O=C([C@@H](NC([C@H](NC([C@@H](NC([C@H](CC(NCCCC[C@H](NC1=O)C(N)=O)=O)NC([C@@H](NC(C)=O)CCCC)=O)=O)CC2=CN=CN2)=O)CC3=CC4=C(C=CC=C4)C=C3)=O)CCCNC(N)=N)N[C@H]1CC5=CNC6=CC=CC=C56
Molecular Formula
C54H71N15O9
Molecular Weight
1074.24
References & Citations
[1]Grieco P, et al. Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. Peptides. 2007 Jun;28 (6) :1191-6.|[2]Nogueiras R, et al. The central melanocortin system directly controls peripheral lipid metabolism. J Clin Invest. 2007 Nov;117 (11) :3475-88.|[3]Kooijman S, et al. Inhibition of the central melanocortin system decreases brown adipose tissue activity. J Lipid Res. 2014 Oct;55 (10) :2022-32.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
MC3R; MC4R; MC5R
Available Sizes
Frequently Asked Questions
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