SHU 9119

SHU 9119 is a potent human melanocortin 3 and 4 receptors (MC3/4R) antagonist and a partial MC5R agonist; with IC50 values of 0.23, 0.06, and 0.09 nM for human MC3R, MC4R and MC5R, respectively.

Product Specifications

CAS Number

[168482-23-3]

UNSPSC

12352209

Target

Melanocortin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/SHU_9119.html

Purity

99.95

Solubility

H2O : 10 mg/mL (ultrasonic)

Smiles

O=C([C@@H](NC([C@H](NC([C@@H](NC([C@H](CC(NCCCC[C@H](NC1=O)C(N)=O)=O)NC([C@@H](NC(C)=O)CCCC)=O)=O)CC2=CN=CN2)=O)CC3=CC4=C(C=CC=C4)C=C3)=O)CCCNC(N)=N)N[C@H]1CC5=CNC6=CC=CC=C56

Molecular Formula

C54H71N15O9

Molecular Weight

1074.24

References & Citations

[1]Grieco P, et al. Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. Peptides. 2007 Jun;28 (6) :1191-6.|[2]Nogueiras R, et al. The central melanocortin system directly controls peripheral lipid metabolism. J Clin Invest. 2007 Nov;117 (11) :3475-88.|[3]Kooijman S, et al. Inhibition of the central melanocortin system decreases brown adipose tissue activity. J Lipid Res. 2014 Oct;55 (10) :2022-32.