JH-X-119-01 (hydrochloride)

JH-X-119-01 hydrochloride is a potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 hydrochloride ameliorates LPS-induced sepsis in mice[1].

Product Specifications

CAS Number

[2591344-30-6]

UNSPSC

12352005

Target

IRAK

Type

Reference compound

Related Pathways

Immunology/Inflammation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/JH-X-119-01_hydrochloride.html

Purity

99.14

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C=C)NC1=CC=CC(C(NC2=CC=C(NC(C3=NC(C4=CC=NN4)=CC=C3)=O)C=C2)=O)=C1.Cl

Molecular Formula

C25H21ClN6O3

Molecular Weight

488.93

References & Citations

[1]Bin Pan, et al. Selective inhibition of interleukin-1 receptor-associated kinase 1 ameliorates lipopolysaccharide-induced sepsis in mice. Int Immunopharmacol. 2020 Aug;85:106597.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

IRAK1

Citation 01

Emerg Microbes Infect. 2024 Dec;13 (1) :2300452.|Sci Adv. 2024 Nov 29;10 (48) :eadq8122.|University of Louisville. 2023 May 24.|JCI Insight. 2022 Jul 8;7 (13) :e149825.|The Ohio State University. 2025.