Treosulfan
Treosulfan (NSC 39069) is a bifunctional alkylating agent with activity in ovarian cancer and other solid tumor types.
Product Specifications
CAS Number
299-75-2
Product Name Alternative
NSC 39069; Treosulphan
UNSPSC
12352100
Hazard Statement
H340, H350, H361
Target
DNA Alkylator/Crosslinker
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Treosulfan.html
Purity
98.0
Solubility
DMSO : ≥ 100 mg/mL|H2O : 50 mg/mL (ultrasonic)
Smiles
O[C@H]([C@@H](O)COS(C)(=O)=O)COS(C)(=O)=O
Molecular Formula
C6H14O8S2
Molecular Weight
278.30
Precautions
H340, H350, H361
References & Citations
[1]Nitsch E, et al. Synergistic cytotoxic activity of treosulfan and LY 188011 in pancreatic cancer cell lines. Anticancer Res. 2014 Apr;34 (4) :1779-84.|[2]Peter T, et al. Programmed erythrocyte death following in vitro Treosulfan treatment. Cell Physiol Biochem. 2015;35 (4) :1372-80.|[3]Sjöö F, et al. Myeloablative and immunosuppressive properties of treosulfan in mice. Exp Hematol. 2006 Jan;34 (1) :115-21.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
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