Treosulfan

Treosulfan (NSC 39069) is a bifunctional alkylating agent with activity in ovarian cancer and other solid tumor types.

Product Specifications

CAS Number

[299-75-2]

Product Name Alternative

NSC 39069; Treosulphan

UNSPSC

12352100

Hazard Statement

H340, H350, H361

Target

DNA Alkylator/Crosslinker

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Treosulfan.html

Purity

98.0

Solubility

DMSO : ≥ 100 mg/mL|H2O : 50 mg/mL (ultrasonic)

Smiles

O[C@H]([C@@H](O)COS(C)(=O)=O)COS(C)(=O)=O

Molecular Formula

C6H14O8S2

Molecular Weight

278.30

Precautions

H340, H350, H361

References & Citations

[1]Nitsch E, et al. Synergistic cytotoxic activity of treosulfan and LY 188011 in pancreatic cancer cell lines. Anticancer Res. 2014 Apr;34 (4) :1779-84.|[2]Peter T, et al. Programmed erythrocyte death following in vitro Treosulfan treatment. Cell Physiol Biochem. 2015;35 (4) :1372-80.|[3]Sjöö F, et al. Myeloablative and immunosuppressive properties of treosulfan in mice. Exp Hematol. 2006 Jan;34 (1) :115-21.