OAT-2068
OAT-2068 is a selective, high activity and orally active inhibitor of mouse chitotriosidase (mCHIT1) (IC50=29 nM) and displays 143-fold selectivity over m AMCase (IC50=4170 nM) . OAT-2068 displays a good pharmacokinetic profile and is an ideal tool to study the role of CHIT1 in biological systems, including animal models of human diseases[1].
Product Specifications
CAS Number
2221950-65-6
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/oat-2068.html
Solubility
10 mM in DMSO
Smiles
NC1=NNC(N2CCC(N3[C@@H](CC4=CC=C(Cl)C=C4)CN(CC(C)C)[C@@H](C)C3)CC2)=N1
Molecular Formula
C23H36ClN7
Molecular Weight
446.03
References & Citations
[1]Marzena Mazur, et al. Discovery of selective, orally bioavailable inhibitor of mouse chitotriosidase. Bioorg Med Chem Lett. 2018 Feb 1;28 (3) :310-314.|[2]Gleb Andryianau, et al. Benzoxazepine-Derived Selective, Orally Bioavailable Inhibitor of Human Acidic Mammalian Chitinase. ACS Med Chem Lett
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
bs-19893R-BF350 100 µL
Phospho-Src (Ser75) Polyclonal Antibody, AbBy Fluor™ 350 Conjugated
Sign In for Pricing
View Details 
MBS7078988 Inquire
Recombinant Saccharomyces cerevisiae Uncharacterized membrane protein YOR034C-A (YOR034C-A) , partial
Sign In for Pricing
View Details 