Withaphysalin D

Withaphysalin D is a selective antagonist against the N-methyl-D-aspartate receptor (NMDAR) containing GluN2B. Withaphysalin D can be isolated from water lilies and has neuroprotective properties. Withaphysalin D is able to cross the blood-brain barrier[1].

Product Specifications

CAS Number

[91599-21-2]

UNSPSC

12352005

Target

IGluR

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/withaphysalin-d.html

Solubility

10 mM in DMSO

Smiles

CC(C[C@@H]([C@@]1(OC([C@]23CC[C@@H]4[C@]5(C(CC=CC5=CC[C@H]4[C@@]2(CC[C@@H]31)O)=O)C)=O)C)O6)=C(C)C6=O

Molecular Formula

C28H34O6

Molecular Weight

466.57

References & Citations

[1]Kumar G, et al. Exploring neuroprotective potential of Withania somnifera phytochemicals by inhibition of GluN2B-containing NMDA receptors: An in silico study. Med Hypotheses. 2016 Jul;92:35-43.