CUMI-101

CUMI-101 (compound 8) is a 5-HT1AR agonist (Ki=0.15 nM) with an EC50 of 0.1 nM in the [35S]GTPγS binding assay. CUMI-101 can be used in the research of neurological diseases[1].

Product Specifications

CAS Number

[179756-61-7]

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cumi-101.html

Smiles

O=C(N(N=CC1=O)CCCCN2CCN(CC2)C3=CC=CC=C3OC)N1C

Molecular Formula

C19H27N5O3

Molecular Weight

373.45

References & Citations

[1]Kumar J S D, et al. Synthesis and evaluation of arylpiperazines derivatives of 3, 5-dioxo- (2H, 4H) -1, 2, 4-triazine as 5-HT1AR ligands[J]. Bioorganic & medicinal chemistry letters, 2014, 24 (19) : 4759-4762.